Center of excellence for particle size reduction services
Lonza Quakertown serves as our US Center of Excellence for particle size reduction and control services for biopharmaceutical drug substances and excipients. The Quakertown site - and its European equivalent in Monteggio CH - is an integral component of our drug product design, development and manufacturing services network. Particle size reduction through micronization is a core strength of Lonza, and a key component of our integrated product development services across drug substances and finished oral solid and inhaled drug products. Particle size reduction and control services are provided across the development cycle, supporting feasibility studies, clinical studies and commercial manufacture.
Stability, flowability, dissolution rate and bioavailability are all critical formulation parameters impacted by drug substance and excipient particle size distribution. We are well versed in particle size reduction to low-micron and sub-micron level, which can be critical in meeting target product profiles. Our product development teams utilize specialized and phase-appropriate jet and other mills to ensure robust process development and rapid scale-up.