Check out Christopher's recent publications:
Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs
This peer-reviewed publication highlights how amorphous solid dispersion dosage forms can improve patient compliance and efficacy of acalabrutinib and other weakly basic drugs that have pH-dependent absorption.
A Novel Architecture for Achieving High Drug Loading in Amorphous Spray-Dried Dispersion Tablets
Although amorphous solid dispersions (ASDs) effectively increase bioavailability, tablet mass can be high due to the large fraction of excipients needed. This publication describes work to reduce the mass of an ASD tablet made from rapidly crystallizing drug with a low glass-transition temperature (Tg). A high-loaded dosage form (HLDF), made by strategically combining two polymers within the tablet, was used to reduce tablet mass by 40%. The resulting formulation had similar physical stability and in vitro...
A Novel Architecture To Enable High Active Loading of Tablets of Amorphous Spray-Dried Dispersions
Amorphous spray-dried dispersions (SDDs) can enhance the oral bioavailability of low-solubility compounds but SDD drug products can suffer from high pill burden. This presentation shows the successful use of a novel architecture to reduce the pill burden of an SDD by strategically combining two different functional polymers in a tablet versus using a single polymer. The pill burden was reduced by 40%, while physical stability and in vitro...
Application of Fundamental Relationships and Models to Predict Spray-Dried Dispersion Particle Size
This presentation describes a process-development strategy that combines fundamental relationships with empirical correlations to produce an accurate modeling technique for correlating predicted droplet size with the final size of spray-dried dispersion (...