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Allogeneic cell therapy stands out in the field of cell and gene therapy for its scalability requirements with challenges similar to those of traditional biologics. A key challenge is the ability of the allogeneic manufacturing platforms to support growth of living cells for a large patient pool. The right partner can help you accomplish this and establish a robust, efficient, and scalable process that meets commercial demand. As you navigate in the evolving cell and gene environment, trust in your partner to deliver becomes critical. Flexible capacity to grow with your project will come into play and become an underlying key success factor for the long run.

Careers

We are looking for candidates to join our team across our global network of sites. Click here to see the positions available:

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iPSC manufacturing expertise

the next wave in cell therapy

We can help you overcome scalability challenges by offering expansion from 2D platforms to closed systems with our proprietary L7 GMP platform services. We have developed manufacturing processes to help you achieve scalable production in a GMP setting.

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Tissue sourcing & acquisition

Our in-house Bone Marrow Donor Program’s dedicated full-time staff can help you to navigate through the complexities of tissue sourcing to obtain the clinical and commercial starting material you need.

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Cell-based immunotherapies

Whether you are developing an autologous or an allogeneic CAR-T therapy you will be focused on a similar goal, but will face very different obstacles, each with its own complexities. Let’s address those, together.

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Exosomes development and manufacturing

Leverage our knowledge in 2D/3D cell culture and viral manufacturing expertise, alongside the latest exosome characterization technologies to define your complete path for exosome manufacturing.

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Regulatory support dedicated to cell & gene therapy

Rely on a dedicated regulatory partner for the expertise and experience you need to de-risk your therapy's pathway.

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Supporting your therapy from concept to patient


By partnering with us, you partner with a growing team of scientists who have expertise in the development and manufacture (isolation, generation, banking, expansion and/or differentiation) of a broad spectrum of cell types including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), T-cells, natural killer cells (NK cells) and many others.

First-class expertise in manufacturing a broad spectrum of cell therapies


Cell and Product Type Capabilities
Induced pluripotent stem cells (iPSC)
  • Reprogramming from cord blood, peripheral blood, fibroblasts, and bone marrow derived cells
  • Expansion in 2D and computer-controlled 3D bioreactors
  • Directed differentiation into all three lineages (ectodermal, endodermal and mesodermal) in 2D and computer-controlled 3D bioreactors
T-cells and Natural killer (NK) cells
  • Viral and non-viral genetic modification for CAR knock-in and TCR knock-out
  • Expansion in 2D and computer-controlled 3D manufacturing systems
Mesenchymal stem cells (MSC)
  • Cell isolation from several tissues
  • Expansion in large-scale 2D and computer-controlled 3D bioreactor
Exosomes and other extracellular vesicles (EVs)
  • Generation from different cell lines in 2D and computer-controlled 3D bioreactor
  • Isolation, characterization and fill & finish
Hematopoietic stem cells (CD34+ stem cells)
  • Viral and non-viral genetic modification and differentiation into different hematopoietic lineages
  • Expansion in 2D and computer-controlled 3D manufacturing systems
Human pluripotent stem cells (hPSCs)
  • Expansion in 2D and computer-controlled 3D bioreactors
  • Directed differentiation into all three lineages (ectodermal, endodermal and mesodermal) in 2D and computer-controlled 3D bioreactors
β-cells
  • Differentiation from pluripotent stem cells and iPSCs in 3D computer-controlled bioreactor culture
Neurons
  • Neural stem cells, motor neuron and dopaminergic neuron differentiation from pluripotent stem cells and iPSC in 2D culture
Immortalized and engineered cell lines
  • Expansion in 2D and computer-controlled 3D manufacturing systems
Tissue engineered product
  • Expansion and maintenance in 2D cell culture systems

Technologies:


Our allogeneic services are based on a technology portfolio that enables robust and cost-efficient manufacturing for high production volumes of a single donor’s living cells.

technology
3D bioreactor manufacturing for cell therapies
Scale up your allogeneic cell therapy with a robust, reproducible process, leveraging our extensive experience transferring processes from 2D to 3D.
technology
MODA-ES®
Bringing the Power of Paperless Execution to Quality and Manufacturing. The MODA-ES® Platform facilitates an innovative and cost effective transition from paper-based batch records to electronic record-keeping. Learn more.
technology
Exosomes development and manufacturing
Leverage our knowledge in 2D/3D cell culture and the latest exosome characterization technologies to define your complete path for exosome manufacturing.
technology
iPSC manufacturing expertise
Proprietary cGMP iPSC custom generation services for tailor-made, fully cGMP iPSC produced at highest quality, with a clear licensing path.
technology
Nucleofector™ Products
Nucleofector™ Products for efficient non-viral modification of primary cells, enabling generation of iPSC or CAR-T cells, or CRISPR-mediated engineering.
technology
TheraPEAK™ Products
Discover our series of GMP solutions for cell expansion, cryopreservation and genetic modification enabling you to take your therapy from discovery through to commercialization. Learn More.

Why choose us?

  • 20+ years of cell and gene therapy GMP expertise
  • >120 process development projects in cell and gene therapy
  • World's first reported iPSC GMP bank
  • Scale-up expertise with 2D and 3D manufacturing platforms
  • >75 allogeneic cell therapy customers served globally
  • Expertise and regulatory consulting throughout your journey
  • Tissue acquisition dedicated team
  • An integrated offer of meda/buffers, viral and non-viral modification and consumables

cell and gene therapies


allogeneic cell therapy centers of excellence

Houston, TX, USA

Clinical Manufacturing, Commercial Manufacturing, Cell and Gene Manufacturing, Viral Vector Manufacturing

14905 Kirby Dr
Houston, TX 77047
United States of America

Geleen, The Netherlands

Clinical Manufacturing, Commercial Manufacturing, Cell and Gene Manufacturing, Process Development, Analytical Development

Urmonderbaan 20B
Geleen
Netherlands

Portsmouth, NH, USA

Clinical Manufacturing, Commercial Manufacturing, Cell and Gene Manufacturing

101 International Drive
Portsmouth, NH 03801
United States of America

Tuas, Singapore

Production, Sales & Support

35 Tuas South Ave 6
Tuas 637377
Singapore