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R&D to support your small molecule API needs


We offer a broad spectrum of research and development services using state-of-the-art chemical technologies. To achieve robust and efficient process qualification for scale-up, we use modern tools such as automated workstations, statistical software, and reaction calorimetry.

  • Evaluation and route scouting for early phase or potential projects
  • Process development and technology transfer for small molecule APIs in early phase
  • Development and optimization of chemical processes
  • Kilo-lab and small scale production under ISO or cGMP standards
  • Process optimization via simulation
  • Analytical and testing services including identification of impurities and characterization of API products and intermediates

We provide cost competitive manufacturing on an industrial scale by placing focus on minimizing the number of unit operations of chemical processes and through specialized quality control and quality assurance expertise.


We focus on customer technology, regulatory and development needs, to deliver:

  • Feasibility studies which include: development of innovative processes and 2nd generation processes (1-3 months)
  • Small scale quantities (10–100 kg, 3–10 chemical steps; APIs) (2-3 months)
  • Process development production of launch quantities (100 kg –5 tons), full regulatory support, validated processes (APIs, HPAPIs) (3-6 months)
  • Support of direct technology transfers from clients to our industrial plants (1-3 months)
More than 70% of global pharmaceutical sales are based on small molecules (IQVIA, March 2018)

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Emerald Health & Lonza collaboration

Full range of chemical synthesis to meet your program needs


Our R&D and manufacturing teams have experience in many types of advanced chemical synthesis techniques. We are always prepared to adopt and optimize your process or offer you many advanced techniques of our own. In either case, our team can provide you with successful development technologies for all of your chemical needs.

Our Advanced Chemical Synthesis Technologies Include:

Technology Example
Hazardous and Highly Reactive Chemicals HCN, ClCN, chlorosulfonyl isocyanate, SOCl2,
Cl2 (gas/liquid), ketene, diketene, phosgene
(cGMP), CO, acetylene, ethylene
Organometallic Reactions Grignard, organolithium, sodium in liquid
NH3, organozinc reactions, Heck reactions,
Suzuki cross-couplings
Reductions Catalytic hydrogenation (homogeneous and
heterogeneous), metal hydrides (NaBH4, LiAIH4),
Raney nickel
Oxidations With ozone (batch and continuous), peroxides,
oxygen/air, nitric acid, ammoxidation
Reactions Under Special Conditions

Low-temperature reactions (-90°C)
High-temperature reactions (+250°C)
High-pressure reactions (10–100 bar)

Asymmetric Reactions Transition metal catalysts
(hydrogenation, oxidation, Heck/Aldol),
biocatalysts, racemic separation,
use of chiral building blocks


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