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The depth of our bioavailability (BA) enhancement offering makes us a leader in addressing drug solubility and dissolution rate issues. We work collaboratively with our customers to advance compounds, or re-purpose existing compounds, across a full range of API properties and delivery challenges. Our end-to-end solutions incorporate full capabilities in bringing a compound from concept to commercialization, thereby minimizing program complexity, timelines and risk.

Industry estimates indicate that more than 80% of new chemical entities exhibit poor solubility or dissolution rate. Effectively addressing these patients is essential for advancing the compound and providing the desired therapeutic benefit of the drug product to patient. And ensuring that the solubility solution incorporates the ultimate manufacturability of the drug product can avoid time-consuming re-formulation and rapid advancement to market.

We recognize the core challenges of progressing the new chemical entities in today’s biopharmaceutical pipeline. That’s why we have developed a portfolio of technologies and services with which to address poor solubility and inadequate or inconsistent dissolution rate.

Our commitment to our customers includes a 20+ year track record across our technology approaches with phase-appropriate processing in place to support non-GMP feasibility assessments through GMP clinical trials and commercial-scale manufacturing.

Proven bioavailability enhancement technologies

Our bioavailability enhancement technologies include:

  • Particle size reduction: micronization and nano-milling
  • Solid dispersion technologies: hot-melt extrusion or spray drying
  • Lipid / liquid based formulations: liquid-filled hard capsule technology or soft gel approaches  
  • Specialized nanocrystalline dispersion and spray-dried nanoadsorbate technologies

Complementary drug delivery technologies are utilized to modulate pharmacokinetics of the solubilized compound and achieve a full range of absorption profiles.

Our scientists take a data-driven approach to characterizing BA problem statement(s) and selecting the enabling technology to advance your compound.

Our integrated product design and development services provide the full range of capabilities to support the rapid advancement of compounds from concept to clinic. This range of services has been integrated in our SimpliFiH(TM) Solutions offering designed to be phase-appropriate and to simplify your pathway to IND/IMPD studies:

  • API development and supply
  • API characterization
  • Product design and preformulation development
  • Formulation and product development
  • Analytical services and quality control
  • Clinical trial manufacture
  • Clinical packaging and supply services

Additionally, our SimpliFiH® Solutions integrated service package is designed specifically to rapidly advance compounds to first-in-human studies.

Industry estimates indicate that more than 80% of new chemical entities exhibit poor solubility or dissolution rate.

Technologies and products

technology
Solid Dispersion Technology
Amorphous solid dispersions are a proven approach to alter the properties of APIs for improved dissolution rate, solubility and overall bioavailability.
technology
Spray Drying Technology
Pioneered for pharmaceutical applications by Bend Research (now Lonza), spray drying has emerged as a primary technology for addressing poor dissolution rate, solubility and bioavailability.
technology
Technology Selection
We have developed models, reference tools and methodologies to accelerate technology selection for BCS II compounds.
technology
Hot Melt Extrusion
Hot-melt extrusion (HME) technology is an established solid dispersion technology for improving dissolution rate and solubility, and a component of our premier bioavailability enhancement services.
technology
Liquid-Filled Hard Capsule Technology
Liquid-filled hard capsule technology has a proven track record in addressing a range of complex formulation challenges inclusive of solubility/bioavailability and low dose/highly potent issues. We provide integrated services for LFHC development and manu...
technology
Micronization & Jet Milling
Particle size reduction is increasingly utilized to address a range of formulation issues facing oral solid and inhaled dosage forms. Stability, flowability, dissolution rate and bioavailability are critical performance parameters impacted by particle siz...
service
SimpliFiH® Solutions: First-in-Human Services
We can provide integrated drug substance and drug product services for preclinical studies and phase I clinical trials.
technology
Soft Gelatin Capsules
Softgels provide an important dosage technology that can be highly beneficial in addressing a wide array of formulation challenges, such as bioavailability enhancement and low dose/HPAPI applications including hormones.
We have advanced thousands of bioavailability-challenged molecules over a 25+ year history across all enabling technologies

small molecules and intermediates

Bend, OR, USA

Production, Sales & Support, Research & Development

1201 NW Wall St.
Bend, OR 97703
United States of America

Quakertown, PA

Production

20 Pacific Dr.
Quakertown, PA 18951
United States of America

Monteggio, Switzerland

Production, Research & Development, Sales & Support

Via Cantonale 4
Monteggio 6998
Switzerland

Ploërmel, France

Production, Research & Development

ZI de Camagnon
Ploermel 56800
France

Edinburgh, Scotland

Production, Research & Development

Oakbank Park Way
Units 4,5 & 6
Livingston EH53 0TH
United Kingdom

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Formulation & Product Development
Lonza provides integrated preformulation, formulation and product development services to our biopharmaceutical customers using a broad range of enabling technologies to address formulation challenges.
Modified & Targeted Delivery
Lonza utilizes a full range of established modified release technologies, often in combination with solubility-enhancing technologies, to meet target product profiles.