The gold standard for fast-track protein expression 

In drug development, it can be a challenge to scale and commercialize new products that depend upon mammalian and microbial processes. To accelerate production, developers need efficient and regulatory-compliant expression systems that can be scaled quickly and reproducibly to meet future needs. With our portfolio of expression platforms and our extensive experience with mammalian and microbial processes, we can help you develop robust, efficient, scalable and regulatory-compliant processes to equip you for ultimate commercial success.


Advanced expression options for your evolving needs

Depending on your needs, you can either take our advanced technologies in your laboratory under a license or rely on Lonza to do it for you. These include our GS Gene Expression System® mammalian platform and XS Technologies® microbial platform. Proprietary technology and expertise at the core of our expression platforms.

Mammalian

GS Gene Expression System® supports the optimal expression and production of monoclonal antibodies and next generation biologics.
  • The complete system includes host cell lines, vectors, access to optimized media and feeds, and process expertise
  • GS Xceed®  is the industry-known host cell line for stable high titers and productivity
  • GS piggyBac® transposon technologyis now part of the system that is helpful to overcome the challenge of complex protein expression
  • POTELLIGENT® CHOK1SV® host cell line with glycosylation engineering enables production of recombinant antibodies with enhanced ADCC activity

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The Lonza GS®Gene Expression System has proven success, enabling expression of more than 60 commercial products, with hundreds more in the clinical pipeline.

Microbial


Our XS Technologies® platform includes Pichia pastoris and Escherichia coli expression systems. With a selection of microbial multi-host systems, you can address a diverse range of molecules.

  • XS® Pichia Expression System is the best in class for complex, non-glycosylated protein production
  • XS® E. coli is one of the most trusted and established organisms for the expression of simple to moderately complex biologics

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Our XS®microbial expression systems are high-yielding, with high strain viability for improved product quality

Easy access to powerful and proven technologies

With Lonza you have a choice to access our technologies for use in your lab or partner with our Mammalian or Microbial services business. These are interchangeable throughout development and manufacture, depending on your needs. Either way, you have access to extensive technology offerings with a collection of proven proprietary, highly productive and scalable mammalian and microbial platforms. By focusing on your research challenges with your ultimate goal in mind, we can help you select the best expression system for your requirements.

  • Research Evaluation License gives you the flexibility to use these systems in your own laboratory to generate unlimited numbers of cell lines that express your desired proteins.
  • Commercial License (single or multi-product) is needed once your product has progressed to clinical filing.
  • All our expression technologies are portable for use yourself or your partners under a research or commercial license.

 

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To learn more about GS System®
Our GS Xceed® Expression System is a robust, fully integrated, scalable mammalian expression platform for producing recombinant therapeutic proteins. Our extensive technical...
To learn more about XS Technologies®
With over 30 years of experience in microbial expression, we can help you optimize the production of biotherapeutics. Our versatile XS Technologies® offer an extensive microbial...