Assess B Cell response to adjuvants

 

The Epibase® in vitro adjuvant assay is a unique offering to vaccine developers. It is used to assess the B cell response to different vaccine adjuvants in combination with the immunizing antigen. The assay can be used as pre-selection to or as an alternative to animal studies.

  • FluoroSpot method used for the detection of total and antigen-specific IgM/IgG production at the single cell level
  • Quantitative measurement of antibody-secreting cells after in vitro immunization
  • Results allow for the determination of the most efficacious adjuvant / antigen combination
  • Assay can be performed in combination with T cell assays for analysis of humoral and cellular immune responses