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Chemistry expertise


Chemistry is core to Lonza. We continue our commitment to using standard and advanced chemical technologies to deliver APIs and intermediates to our customers. Our process development teams are experts in optimizing the selected synthesis route. And our experience and track record in advancing thousands of molecules demonstrates leadership across an extensive range of chemical product platforms and technologies.

  • Alkylations
  • Acetylene / Ethylene Couplings
  • Aminations
  • Ammonoxidation
  • Antibody-Drug Conjugates
  • Asymmetric Reactions
  • Biocatalysis 
  • Brominations
  • Carbonylations
  • Chlorinations
  • Coupling of Unstable Intermediates
  • C-C Bond Formation
  • Dehydrogenation
  • Diazotations
  • Diels-Alder Additions
  • Diketene Reactions
  • Emulsion Reactions
  • Enzymatic Reactions 
  • Esterifications
  • Ethoxylations
  • Friedel-Crafts Reactions
  • Grignard Reactions          
  • Halogenations
  • High-pressure Reactions
  • Hydrations
  • Hydrogenations
  • Isomerizations
  • Microreactions / Continuous Flow Technology
  • Methylations
  • Nitrations
  • Nitrosations
  • Organolithium Reactions
  • Organometallic Reactions
  • Oxidations
  • Ozonolysis
  • Phosgenations
  • Quaternizations
  • Reductions with Metals / Metalhydrides / DIBAL
  • Saponifications
  • Simmons-Smith Reactions
  • Solid-phase Synthesis (peptides)
  • Wittig Reactions
  • Many more
Chemistry still accounts for the majority of today’s drug development pipeline (IQvia Annual DCAT Review, March 2018).

Integrated chemistry expertise for small molecules


Our integrated development and manufacturing sites in Visp (CH) and Nansha (China) provide advanced chemical synthesis services inclusive of:

  • Hazardous and highly reactive chemicals
  • Organometallic reactions
  • Reductions
  • Oxidations
  • Asymmetric reactions

We also support reactions under special conditions inclusive of low-temperatures, high temperatures and high pressures. 

Synthesis of potent and highly potent intermediates and APIs is fully supported at our Visp location. We provide HPAPI and ADC payload development services across all standard chemical reactions for highly potent applications to 1 ng/m³. Our kilo-lab has full capabilities in sample preparation, ISO and cGMP production for feasibility and early phase clinical projects.

Chemical synthesis technologies are fully supported with extensive process development and intensification. Complementary capabilities in particle engineering – jet milling, spray drying or hot melt extrusion – are employed to prepare drug compounds for formulation to target product profiles.

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BA Enhancement
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