reduce particle size with expert micronization and jet milling

Using high velocity compressed gas, jet milling accelerates particles to supersonic speeds to achieve sub-10 micron particle distributions. A compressed gas source is used for accelerating API particles in a tornado-like flow path within the grinding chamber of the jet mill. As particles travel in the circular path, particle-on-particle attrition is effected and particle size reduction occurs. Large particles continually migrate to the outside of the mill via centrifugal force while micronized particles migrate to the center mill outlet via drag force. 

The resultant superfine particles have Gaussian distribution curves with excellent reproducibility. The process is conducted at ambient conditions due to the instantaneous pressure drop of the grinding gas within the milling chamber, cooling and colliding particles which makes jet milling an ideal technology for sensitive pharmaceutical ingredients.  Pressure, feed rate and proprietary mill design attributes are utilized to influence particle size distribution.

Highly Potent Compounds - High containment capabilities support particle size reduction of high potent and cytotoxic compounds. A range of mechanical and jet milling capabilities are used within isolators or glove boxes designed to meet containment levels to 1mcg / cubic meter

Cryogenic Micronization - For APIs with elastic or semi-solid properties, Lonza utilizes this technology to meet target particle size distributions. Liquid nitrogen gas allows for chilled jet milling at extremely low temperatures (to -30C), which results in more friable powder and facilitates improved particle size reduction than is possible at ambient conditions.