Multiparticulate (MP) technologies are heavily utilized for today’s increasingly specialized medicines and focus on patient-centricity. Multiparticulates are highly flexible in terms of meeting required drug delivery profiles, incorporating taste and odor masking, multiple dose ranges and ease of administration.
MP formulations continue to grow in application due to their inherent advantages, including the greater flexibility they offer compared with monolithic formats:
- offer a wide range of flexibility in drug-release profile for single or multiple drug combinations and enable formulation as modified release, immediate release, bioavailability-enhanced, and/or taste-masked dosage forms
- provide predictable and consistent GI transit and lower chances of undesirable events associated with tablets (e.g. dose dumping)
- can be formulated into encapsulated, tablet or sachet formats
- can facilitate ease of swallowing, an attribute increasingly important in targeted medications for pediatric and geriatric populations
We utilize four distinct and proven MP technologies for designing and developing drug products. The selection of a specific MP technology is typically dependent upon the API characteristics and target product profile.