Taste masking approaches
Effective taste and odor masking has been shown to have a marked effect on patient compliance, especially for specialized patient populations such as pediatrics and geriatrics. We have utilized our drug design and formulation expertise to develop an array of effective taste-masking approaches, the choice of which is dependent upon API parameters, target product profile and the commercial objectives of your specific compound.
Taste masking is typically accomplished in one of three ways:
- Using sweeteners, flavors, and viscosity modifiers to manipulate the perception of taste without changing the concentration of free drug in solution
- Preferentially binding the drug to a substrate that reduces the free-drug concentration, ideally below the taste threshold
- Applying functional coatings that modify the release of the drug, keeping the free-drug concentration below the taste threshold for a time period relevant to the preparation and administration of the dose
Our product development teams use all three approaches dependent on the specific application, however, the third option is typically the most effective in our experience.