United States, Houston (Texas)

Today Lonza is a global leader in life sciences. We are more than 15,000 employees in more than 100 locations around the world. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Experienced in development and optimization of cell culture processes for the production of cell and gene therapy products. The successful candidate should have experience with primary cell and tissue isolation techniques, maintenance, expansion, and differentiation of stem cells including pluripotent stem cells, Mesenchymal Stem cells, in vitro culture of T and NK cells and/or primary cells derived from human tissue, in vitro culture of adherent and suspension cell lines, gene modification and transfection / transduction techniques, downstream and fill/finish processing.  She/he should be able to assist both technical scientists and management in the design and execution of new or unique cell-based projects; be able to assist with tech transfer of processes to manufacturing and design of investigation studies for Manufacturing Sciences and Technology (MSAT) and manufacturing team; be able to train and mentor other technical scientists and manufacturing personnel in the development and / or execution of developed process plans; analyze bioprocessing data to monitor, optimize and determine limits of process performance. She/he should be able to present data and clearly communicate the results of process development studies with the clients. Experience with Design of Experiment (DOE) and statistical analysis is preferred.

Key responsibilities:

  • Responsible for successful development and execution of state-of-the-art manufacturing processes for current Good Manufacturing Practices (cGMP) manufacturing within the Cell Therapy Development matrix.
  • Interact with new or existing Cell Therapy clients to document and transfer new processes to Lonza sites and communicate and present the work in meetings.
  • Contribute and support scientific or engineering expertise toward the design and development of new process ideas that support client product concepts.
  • Design and review of experiments of cell process optimization, scale up and cryopreservation, trouble shoot the problems.
  • Oversee the initial technical training of specific Process Development protocols to Cell Therapy Manufacturing Teams.
  • Establish and maintain a good working relationship within the operations department  and other departments such as Research and Technology (R&T), Quality Control (QC), Quality Assurance (QA) and Project Management (PM).
  • Lead, review and/or train/assist in writing and revising technical documents including laboratory SOPs, protocols, reports and batch records.
  • Support Research and Technology (R&T) projects by providing constructive technical feedback and improving new processes as they are being transferred into Cell Therapy Development prior to offering to clients.
  • Perform other duties as assigned.

Key requirements:

  • PhD in Life Sciences with focus on Stem cell Biology, Immuno-oncology, Bioprocessing or Bioengineering with intermediate years of related experience; MS degree in Life Sciences field with advanced years; BS degree with extensive years of related manufacturing or process development experience in biotech industry.
  • Mammalian cell culture experience, and specifically experience with stem cells, immune cells or human primary cells.
  • Preference to familiarity with a GMP environment.
  • Understanding cell-based assays including, but not limited to, morphological assessment, cell proliferation, functional differentiation, cytotoxicity, detection of marker expression (ICC), Flow Cytometry, qPCR and ELISAs.
  • Experience with DOE and statistical analysis is preferred.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Lonza is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a qualified individual with disability, protected veteran status, or any other characteristic protected by law.

Reference: R25783
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