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Support for drug discovery activities with a wide range of bioconjugation technologies from antibody design to sample panel preparation


We have experience with a wide range of bioconjugation technologies. We can perform the cell line construction/strain development, GMP cell banking for your antibody along with the payload and linker manufacturing. We can prepare ADC sample panel to support your drug discovery activities. We can perform in silico and cell based immunogenicity testing on naked antibodies. We can test the naked mAb for aggregation propensity and re-engineer your mAb for site selective conjugation and reduced aggregation.

We are able to offer options to help deliver your product quickly and efficiently for pre-clinical studies. Our streamlined ADC Easy Access program can offer:

  • Preparation of ADC sample panels using a variety of client specified drug-linkers
  • Lab facilities and equipment for milligram-and gram-scale experiments
  • Ability to address various R&D phases based on customer needs
As the industry moves from first generation stochastic conjugation to site-specific conjugation technology, Lonza has developed its own GS® site-specific conjugation constant region vectors. This technology addresses the challenges associated with heterogeneous isoforms observed when performing stochastic conjugation. We have the knowledge in antibody engineering to help find the best possible solution for your program.

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Our GS Gene Expression System® has options to engineer and express conjugation-competent antibodies. Applications include antibody drug conjugates (ADCs), half-life extension and imaging.

Unlike other contract development and manufacturing organizations (CDMOs), we are in the unique position to offer complete development and manufacturing services from both mammalian cell culture and advanced chemical synthesis for the production of Antibody-Drug Conjugates (ADCs). From process development to manufacturing scale-up, we are proud to offer more ways than ever to deliver your product.

technology
GS Xceed® Expression System
Our GS Xceed® Expression System is a robust, fully integrated, scalable mammalian expression platform for producing recombinant therapeutic proteins. Our extensive technical expertise and advanced manufacturing services provide the confidence you need to ...
technology
Chemical Synthesis Technologies
We master an extensive array of chemical platforms and technologies.
View recent articles on complex protein expression
View recent articles on complex protein expression
service
ADC Payload Product Development
We can provide a full-service offering for antibody-drug conjugates (ADC) inclusive of ADC payloads, monoclonal antibodies, linkers and bioconjugation services.
We have 10 years in ADC development and manufacture.