We apply extensive product design, preformulation, and technology expertise to successfully advance challenging compounds and improve overall speed to market. We offer premier depth in addressing bioavailability challenges and modulating pharmacokinetics to meet target product profiles. Recognizing that every molecule presents its own set of challenges, our product development teams combine our unique drug and process design capabilities with a premier range of technologies to deliver the right solution for your drug product.

Building on decades of design, development and scale-up experience over thousands of compounds, our multi-disciplinary project teams routinely develop custom approaches to enhance the bioavailability, efficacy, and performance of drug candidates across oral solid and inhaled product applications. Best practices in compound characterization and technology selection have been developed, as well as specialized processing equipment and techniques that result in robust, scalable solutions and accelerated development timelines. Phase-appropriate processing is in place for oral solid and parenteral product development from proof-of-concept studies, early and late phase clinical trials, and commercial manufacture. 

We focus on robust problem statement definitions and data-driven formulation design to help ensure accelerated development and seamless scale-up

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Formulation selection and in-vitro screening for oral bioavailability enhancement

Product development from proof of concept to commercialization

 

We work together to fully characterize your compound and its problem statements, and tailor the formulation and drug-delivery system to meet rigorous product specifications, even for the most challenging molecules. Our core technologies and expertise address key challenges presented by today's candidate compounds, including:

  • bioavailability enhancement, solubility and dissolution rate issues
  • targeted delivery, extended or delayed release, zero order and dual release 
  • delivery of high-potency and low-dose compounds
  • accelerated screening and development: powder-in-capsule studies
  • abuse-deterrent formulations
  • taste- and odor-masking solutions (pediatrics)
  • pulmonary/inhaled delivery
  • parenteral delivery

We have extensive experience with a range of proven enabling technologies, many of which have been developed or advanced by our teams:

  • solid dispersions
  • particle size reduction 
  • lipid- and liquid-based formulations
  • modified- and targeted-release formulations
  • fixed-dose combinations 
  • multiparticulates
  • engineered particles for inhaled applications
  • sterile fill / finish for parenteral applications

We employ efficient, science-based flowchart methodologies to identify the best formulation and delivery approaches for each drug candidate and then use production and testing capabilities appropriately scaled for each phase of development. Specialized facilities are in place to support highly potent compounds and the use of processes employing organic solvents. 

Our teams have advanced thousands of compounds over a full range of formulation challenges.

Technologies and products

oral drug products and intermediates

Ploërmel, France

Production, Research & Development

ZI de Camagnon
Ploermel 56800
France

Monteggio, Switzerland

Production, Research & Development, Sales & Support

Via Cantonale 4
Monteggio 6998
Switzerland

Bend, OR, USA

Production, Sales & Support, Research & Development

1201 NW Wall St.
Bend, OR 97703
United States of America

Tampa, FL, USA

Production, Sales & Support

4910 Savarese Circle
Tampa, FL 33634
United States of America

Edinburgh, Scotland

Production, Research & Development

Oakbank Park Way
Units 4,5 & 6
Livingston EH53 0TH
United Kingdom

Quakertown, PA

Production

20 Pacific Dr.
Quakertown, PA 18951
United States of America

Visp, Switzerland

Production, Research & Development, Sales & Support

Visp 3930
Switzerland